HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl bromoacetate → 2-Trifluromethyl-4-nitrophenoxyacetic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl bromoacetate | HCID 7748 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Phenol, 4-nitro-2-(trifluoromethyl)- | HCID 3014014 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | 2-Trifluromethyl-4-nitrophenoxyacetic acid ethyl ester | HCID 19261608 | 95% |
Reaction Steps
A mixture of 2-trifluoromethyl-4-nitrophenol (73.4 g, 0.354 mol), ethyl bromoacetate (65.2 g, 0.39 mol), potassium carbonate (58.7 g, 0.425 mol) and 2-butanone (400 mL) was refluxed under stirring for 10 h. The solid was filtered off, the filtrate was evaporated and the residue was fractionated yielding 97.8 g (95%) of 2-trifluromethyl-4-nitrophenoxyacetic acid ethyl ester, b.p. 126° C./40 Pa.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07816385B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-79e7ca7fc78b4de0abd00959d8e0b2bc |
| Source note | uspto-grants-2010_10 |