Sodium Hydroxide → HCID 86595623, compound

Participants

Reaction Steps

To a solution of (S,S)-2-ethoxy-3-{4-[3-(4′-{3-[4-(2-ethoxy-2-isopropoxycarbonyl-ethyl)-phenoxy]-propyl}-2,2′-bis-trifluoromethyl-biphenyl-4-yl)-propoxy]-phenyl}-propionic acid isopropyl ester (example 13) in ethanol (4 ml) was added 1 N NaOH (0.6 ml) at room temperature. The reaction was stirred for 48 hours at room temperature and evaporated. The residue was treated with 1 N HCl and extracted with methylene chloride (2×15 ml). The combined organic phases were dried and evaporated to give the title compound in 105 mg (78%) yield.

Provenance & Evidence