Methanesulfonyl chloride → HCID 87539185, compound

Participants

Reaction Steps

To a solution of 3-[4′-(3-hydroxy-propyl)-3,3′-bis-trifluoromethyl-biphenyl-4-yl]-propan-1-ol (intermediate 6) (5.4 g, 13.3 mmol) in dichloromethane (40 mL) triethylamine (2.5 g, 24.7 mmol) and methanesulfonyl chloride (2.7g, 23.6 mmol) were added dropwise. The mixture was stirred overnight, diluted with dichloromethane (50 mL) and washed with water (2×15 mL). Evaporation of the organic solution gave 3,3′-bistrifluoromethyl-4,4′-biphenyl-dipropanol bismethanesulfonate.

Provenance & Evidence