Sodium Hydroxide → HCID 57815082, compound

Participants

Reaction Steps

The (2R,3S)-3-{[3-[methyl(methylsulfonyl)amino]-5-({[(1R)-1-phenylethyl]amino}carbonyl)benzoyl]amino}-4-phenyl-2-(tetrahydro-2H-pyran-2-yloxy)butanoic acid methylester obtained in Reference Example 26 1.79 g (2.75 mmol) was dissolved in methanol 6 mL and thereto was added 5N aqueous sodium hydroxide solution 1.10 mL under ice-cooling and the mixture was stirred at room temperature for 6 hours. After distillating methanol off, the mixture was washed with ether. The aqueous layer was adjusted with diluted hydrochloric acid to pH 3 under ice-cooling and extracted with chloroform. The organic layer was washed with an aqueous saturated sodium chloride solution and dried on magnesium sulfate, filtered and concentrated to give 1.74 g (2.73 mmol) of the title compound (yield: 99%).

Provenance & Evidence