Sodium Hydroxide → HCID 57815115, compound

Participants

Reaction Steps

To a 10 ml solution of (2R,3S)-2-hydroxy-3-{[3-[methyl(methylsulfonyl)amino]-5-({[(1R)-1-phenylethyl]amino}carbonyl)-benzoyl]amino}-4-phenylbutanoic acid methylester 775 mg (1.37 mmol) in methanol was added 1N aqueous sodium hydroxide solution 1.64 ml and the mixture was stirred at room temperature for 5 hours. After distilling methanol off, the mixture was washed with ether. The mixture was adjusted with 1N hydrochloric acid to pH 3 under ice-cooling and the mixture was extracted with ethyl acetate. The organic layer was washed with an aqueous saturated sodium chloride solution and dried on magnesium sulfate, filtered and concentrated to give the title compound 730 mg (1.32 mmol) (yield 96%).

Provenance & Evidence