Tert-Butylamine → HCID 68423125, compound

Participants

Reaction Conditions

Reaction Steps

(2S)-3-(3-Hydroxyphenyl)-2-isopropoxypropionic acid (7.6 kg, 34 mol) was dissolved in 1,2-dimethoxyethane (131 L), then tert-butylamine (3.9 L, 37 mol) was added dropwise to the reaction mixture at 20° C. over a period of 15 minutes. The reaction mixture was stirred at 75° C. for 2 hours and cooled, followed by separating the generated crystal by filtration. The crystals were subjected to vacuum drying at 40° C. for 23 hours to obtain 9.04 kg of the title compound (yield: 90%).

Provenance & Evidence