Ethyl Bromide → HCID 178463965, compound

Participants

Reaction Conditions

Reaction Steps

A 200 mL flask provided with a stirrer and a reflux condenser was charged in a nitrogen gas atmosphere with 1.2 g (0.05 mol) of metallic magnesium (cut form, 20-50 mesh size) (available from Yamaishi Metals Co., Ltd.), 20.0 g of tetrahydrofuran (available from Kanto Chemical Co., Inc.) and 0.3 g (0.003 mol) of ethyl bromide (available from Kanto Chemical Co., Inc.). The content was heated under reflux of solvent for 30 minutes. Then the reaction liquid was cooled to 5° C., and a solution in 30.0 g of tetrahydrofuran of 15.7 g (0.05 mol) of the p-(N-methyl-N-ethylaminohexyloxy)bromobenzene, synthesized at the above-mentioned step 2), was dropwise added at 5° C. over a period of 1 hour. The mixed reaction liquid was maintained at that temperature for 2 hours while being stirred. Thus a solution in tetrahydrofuran of the target p-(N-methyl-N-ethylaminohexyloxy)phenylmagnesium bromide was obtained.

Provenance & Evidence