(+)-Benzyl 3,3-difluoro-1-hydroxycyclopentanecarboxylate → (+)-3,3-Difluoro-1-hydroxycyclopentanecarboxylic acid

Participants

Reaction Steps

To a solution of (+)-benzyl 3,3-difluoro-1-hydroxycyclopentanecarboxylate (1.8 g, 7.0 mmol) in 45 ml of EtOAc was added a suspension of 10% Palladium on Carbon (720 mg) in 5 ml of EtOAc. The mixture was stirred at room temperature under hydrogen atmosphere for 1 hour (balloon). The reaction mixture was filtered through a glass micropore filter to remove the catalyst and the filtrate was concentrated under vacuum to give (+)-3,3-difluoro-1-hydroxycyclopentanecarboxylic acid.

Provenance & Evidence