HCID 178420350, compound → HCID 178511576, compound

HRID 1160669Notes

Reaction equation

HRID 1160669 reaction equation
C([N:8](CC1C=CC=CC=1)[C@H:9]1[CH2:14][CH2:13][C@H:12]([N:15]2[CH2:20][CH2:19][N:18]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[CH2:17][CH2:16]2)[CH2:11][CH2:10]1)C1C=CC=CC=1>CO.[Pd]>[C:21]1([N:18]2[CH2:17][CH2:16][N:15]([C@H:12]3[CH2:11][CH2:10][C@H:9]([NH2:8])[CH2:14][CH2:13]3)[CH2:20][CH2:19]2)[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

Participants

4

Reactant 1

HCID 178420350HCID 178420350, compound

Product 1

HCID 178511576HCID 178511576, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

270 mg (0.61 mmol) of trans-dibenzyl-[4-(4-phenyl-piperazin-1-yl)-cyclohexyl]-amine were dissolved in 5 mL MeOH and hydrogenated on 40 mg of Pd/C (10%) at 20-30° C. The solvent was eliminated in vacuo and the residue crystallised from ethanol and conc. HCl. Yield: 110 mg (69%).

Workup

  1. customthe residue crystallised from ethanol and conc. HCl

Sources & evidence

ORD record
ord-62b397c8148f4728b503c3badac4e01f
Source dataset
uspto-grants-2010_10
Patent number
US07816530B2

Reaction notes

Loading…