HCID 3152239, compound → 1-Phenethylamine

Participants

Reaction Steps

A solution of N-(1-Phenylethyl)propargylamine (500 mg, 3.1 mmol) in THF (5 ml) was added to the LVT reagent prepared as described in Example 2.1 above, and the resulting mixture stirred for 2 hours at room temperature. The reaction mixture was diluted with hexane-ethyl acetate mixture (70:30) and filtered through celite. The filtrate washed with brine, dried (Na2SO4), and concentrated under vacuum. The crude product was purified using chromatography (SiO2) to yield 1-phenylethylamine (290 mg, 77%). The rotation (αD) of the de-protected 1-phenylethylamine was used to determine the ee of the products in Example 1.11.

Provenance & Evidence