Potassium Carbonate → HCID 24830316, compound

Participants

Reaction Steps

The solution of Compound 100 (60 mg, 0.17 mmol), tosylmethylisocyanide (38 mg, 0.19 mmol) and K2CO3 (50 mg, 0.36 mmol) in MeOH (5 mL) were heated at 90° C. for 40 min before it was filtered and concentrated. The residue was dissolved in EtOAc (10 mL) and H2O (10 mL). The organic phase was collected, dried and concentrated. Column chromatography afforded Compound 23 (47, 65%). 1H NMR (300 MHz, CDCl3) δ 7.64-7.59 (m, 4 H), 7.46-7.40 (m, 1 H), 7.12 (d, J=8.7 Hz, 2 H), 7.01 (t, J=8.1 Hz, 2 H), 6.21 (s, 1 H), 2.49-2.40 (m, 4 H), 1.84-1.76 (m, 4 H); ESMS cacid (C22H18F2N2O2): 380.1; found: 381.1 (M+H).

Provenance & Evidence