Hydrazine → 6-(Propan-2-yl)-4,5-dihydropyridazin-3(2H)-one

HRID 1160763Notes

Reaction equation

HRID 1160763 reaction equation
[CH3:1][CH:2]([CH3:10])[C:3](=O)[CH2:4][CH2:5][C:6](O)=[O:7].[NH2:11][NH2:12]>C(O)C>[CH:2]([C:3]1[CH2:4][CH2:5][C:6](=[O:7])[NH:11][N:12]=1)([CH3:10])[CH3:1]

Participants

4

Reactant 2

HCID 9321HydrazineHCID 389345-Methyl-4-oxohexanoic acid

Product 1

HCID 230280926-(Propan-2-yl)-4,5-dihydropyridazin-3(2H)-one

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

5-Methyl-4-oxohexanoic acid (3.60 g, 25.0 mmol) and anhydrous hydrazine (0.80 g, 26.0 mmol) were heated for 3 hours in ethanol (36.0 ml) under stirring. After the reaction solution was concentrated under reduced pressure, hexane was added to the residues to precipitate crystals, and the crystals were collected by filtration to give 4,5-dihydro-6-isopropyl-3 (2H)-pyridazinone as crystals. The yield was 3.10 g.

Workup

  1. concentrationAfter the reaction solution was concentrated under reduced pressure, hexane
  2. additionwas added to the residues
  3. customto precipitate crystals
  4. filtrationthe crystals were collected by filtration

Sources & evidence

ORD record
ord-3dbb2e47ec2d450cb00e0d1ef5831cda
Source dataset
uspto-grants-2010_10
Patent number
US07816526B2

Reaction notes

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