Hydrochloric Acid → HCID 23028111, compound

Participants

Reaction Steps

60% sodium hydride (0.19 g, 4.75 mmol) was suspended in DMF (5.0 ml) and ethanethiol (0.29 g, 4.6 mmol) was added thereto with stirring. After evolution of hydrogen was ceased, 6-chloro-2-ethylimidazo[1,2-b]pyridazin-3-ylsulfonamide (0.30 g, 1.15 mmol) was added thereto and stirred at 50° C. for 3 hours. After the reaction was completed, the reaction solution was poured into water (50.0 ml) and adjusted to pH 2 with dilute hydrochloric acid, and the precipitated crystals were filtered, washed with water and washed with ether, to give the title compound as pale yellow crystals. The yield was 0.19 g (57.3%).

Provenance & Evidence