反应详情

温度

120 °C

A mixture of 4-butyryl-2-hydroxy-benzoic acid methyl ester (60 mg, 0.27 mmol), (3-chloro-2-fluoro-phenyl)-hydrazine (Apollo Scientific, Ltd., 54 mg, 0.27 mmol), and zinc chloride (110 mg, 0.8 mmol) in acetic acid (2 mL) is purged with nitrogen for 5 minutes and then heated in a sealed tube at 120° C. for 2 hours. The mixture is cooled to room temperature and diluted with ethyl acetate. The resulting mixture is sequentially washed with saturated aqueous Na2CO3 and saturated aqueous NaCl, and finally dried over sodium sulfate. After concentration, the crude product is purified via silica gel flash column chromatography (10% ethyl acetate in hexanes) to afford 4-(6-chloro-3-ethyl-7-fluoro-1H-indol-2-yl)-2-hydroxy-benzoic acid methyl ester as a light yellow solid: ESMS m/z 348.1 (M+H+).

1. customis purged with nitrogen for 5 minutes
2. temperatureThe mixture is cooled to room temperature
3. additiondiluted with ethyl acetate
4. washThe resulting mixture is sequentially washed with saturated aqueous Na2CO3 and saturated aqueous NaCl
5. dry with materialfinally dried over sodium sulfate
6. concentrationAfter concentration
7. customthe crude product is purified via silica gel flash column chromatography (10% ethyl acetate in hexanes)