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Hydrochloric Acid → [4-(Benzyloxy)-3-cyanophenyl]boric acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Triisopropyl borate | HCID 21531 | — |
| 反応物 | 2-(Benzyloxy)-5-bromobenzonitrile | HCID 2237785 | — |
| 反応物 | HCID 178418244 | HCID 178418244 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | [4-(Benzyloxy)-3-cyanophenyl]boric acid | HCID 66995522 | — |
反応手順
2-(Benzyloxy)-5-bromobenzonitrile and triisopropyl borate were dissolved in a mixed solvent of THF and toluene, and at −78° C., an n-butyllithium/hexane solution was dropwise added. This was heated up to room temperature, and 1 M hydrochloric acid was added to the reaction mixture, followed by stirring to obtain [4-(benzyloxy)-3-cyanophenyl]boric acid. ES: 254.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07816558B2 |
| 出典データセット | uspto-grants-2010_10 |
| ORD ID | ord-a0163858732b4daaa60fd5a71fb90d47 |
| 出典メモ | uspto-grants-2010_10 |