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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1160811Generated: October 31, 2026

Thioacetamide → 4-(Benzyloxy)-3-cyanobenzenecarbothioamide

https://huagongshe.com/reaction/1160811

Reaction equation

Participants

RoleNameHCIDCharge
ReactantThioacetamideHCID 2723949—
Reactant4-(Benzyloxy)isophthalonitrileHCID 15326611—
Reactant1,4-Dioxane hydrochlorideHCID 20443148—
SolventDimethylformamideHCID 6228—
Product4-(Benzyloxy)-3-cyanobenzenecarbothioamideHCID 86626137—

Reaction Conditions

Temperature60 °C

Reaction Steps

A 4M HCl/1,4-dioxane solution was added to a DMF solution of 4-(benzyloxy)isophthalonitrile and thioacetamide, followed by stirring at 60° C. to obtain 4-(benzyloxy)-3-cyanobenzenecarbothioamide. AP: 291 (Na).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07816558B2
Source datasetuspto-grants-2010_10
ORD IDord-9ee35466d44346f58464ee35f39dabc0
Source noteuspto-grants-2010_10