HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → HCID 178486330, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | 4,9-Dihydroxy-6,7-bis(2-hydroxypropyl)-1,5,8,12-tetramethoxyperylene-3,10-dione | HCID 130305 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Solvent | Acetic Anhydride | HCID 7918 | — |
| Product | HCID 178486330 | HCID 178486330 | 26% |
Reaction Steps
A solution of Phleichrome (100 mg) in DMSO (2 mL) and acetic anhydride (1 mL) was heated at 40° C. for 24 h. The reaction mixture was diluted by dichloromethane (15 mL), washed with water and evaporated. The residue was chromatographed on two silica gel columns (1-5% MeOH-dichloromethane) to provide Hypocrellin B (25 mg, ˜25%). Thin-layer chromatography results and 1H-NMR were identical to that obtained from naturally occurring and extracted Hypocrellin B from H. bambusae, and as obtained by the two-step chemical conversion (Scheme 2).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07816563B1 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-4ce41e89911e49b0b1d72db862e95566 |
| Source note | uspto-grants-2010_10 |