(4-Fluoro-2-methylphenyl)boronic acid → HCID 59518060, compound

HRID 1160911Notes

Reaction equation

HRID 1160911 reaction equation
C[O:2][C:3](=[O:32])[CH2:4][CH2:5][NH:6][C:7](=[O:31])[C:8]1[CH:13]=[CH:12][C:11]([CH:14]([O:21][C:22]2[CH:27]=[C:26]([CH3:28])[C:25](Br)=[C:24]([CH3:30])[CH:23]=2)[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])=[CH:10][CH:9]=1.[F:33][C:34]1[CH:39]=[CH:38][C:37](B(O)O)=[C:36]([CH3:43])[CH:35]=1>>[F:33][C:34]1[CH:39]=[CH:38][C:37]([C:25]2[C:26]([CH3:28])=[CH:27][C:22]([O:21][CH:14]([C:11]3[CH:10]=[CH:9][C:8]([C:7]([NH:6][CH2:5][CH2:4][C:3]([OH:2])=[O:32])=[O:31])=[CH:13][CH:12]=3)[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])=[CH:23][C:24]=2[CH3:30])=[C:36]([CH3:43])[CH:35]=1

Participants

3

Reactant 2

HCID 2734665(4-Fluoro-2-methylphenyl)boronic acidHCID 67153406HCID 67153406, compound

Product 1

HCID 59518060HCID 59518060, compound

Procedure

This compound is made in a manner substantially similar to Example 117 using isomer 1 of 3-{4-[1-(4-bromo-3,5-dimethyl-phenoxy)-heptyl]-benzoylamino}-propionic acid methyl ester and 4-fluoro-2-methyl-phenylboronic acid as starting materials in step D. MS (ES): 520.2 [M+H]+.

Sources & evidence

ORD record
ord-23de5085b6b2467d9b0a263ca0a029c1
Source dataset
uspto-grants-2010_10
Patent number
US07816557B2

Reaction notes

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