反应详情

To the solution of isomer 1 of 2-Hydroxy-3-{4-[1-(4′-isopropyl-2,6-dimethyl-biphenyl-4-yloxy)-2-methyl-propyl]-benzoylamino}-propionic acid methyl ester (150 mg) in methanol (10 mL) is added sodium hydroxide (5 N aqueous, 1 mL) and stirred for 4 h. The reaction mixture is concentrated and acidified by 5 N HCl (1 mL), extracted with ethyl acetate. Combined organic layers are washed with water and brine, dried over sodium sulfate. Concentration gives the title compound (93 mg) as a white solid. MS (ES): 504.2 [M+H]+.

1. concentrationThe reaction mixture is concentrated
2. extractionextracted with ethyl acetate
3. washCombined organic layers are washed with water and brine
4. dry with materialdried over sodium sulfate
5. concentrationConcentration