4-Isopropylphenylboronic acid → HCID 59518032, compound

HRID 1160944Notes

Reaction equation

HRID 1160944 reaction equation
C[O:2][C:3](=[O:32])[CH2:4][CH2:5][NH:6][C:7](=[O:31])[C:8]1[CH:13]=[CH:12][C:11]([CH:14]([O:21][C:22]2[CH:27]=[C:26]([CH3:28])[C:25](Br)=[C:24]([CH3:30])[CH:23]=2)[CH2:15][CH2:16][C:17]([F:20])([F:19])[F:18])=[CH:10][CH:9]=1.[CH:33]([C:36]1[CH:41]=[CH:40][C:39](B(O)O)=[CH:38][CH:37]=1)([CH3:35])[CH3:34]>>[F:18][C:17]([F:19])([F:20])[CH2:16][CH2:15][CH:14]([C:11]1[CH:10]=[CH:9][C:8]([C:7]([NH:6][CH2:5][CH2:4][C:3]([OH:2])=[O:32])=[O:31])=[CH:13][CH:12]=1)[O:21][C:22]1[CH:27]=[C:26]([CH3:28])[C:25]([C:39]2[CH:40]=[CH:41][C:36]([CH:33]([CH3:35])[CH3:34])=[CH:37][CH:38]=2)=[C:24]([CH3:30])[CH:23]=1

Participants

3

Reactant 2

HCID 27734804-Isopropylphenylboronic acidHCID 67153445HCID 67153445, compound

Product 1

HCID 59518032HCID 59518032, compound

Procedure

The title compounds are prepared in a manner substantially similar to Example 128 starting from enantiomers of 3-{4-[1-(4-bromo-3,5-dimethyl-phenoxy)-4,4,4-trifluoro-butyl]-benzoylamino}-propionic acid methyl ester and 4-isopropyl phenyl boronic acid. Isomer 1 MS: 540.2 [M−H]−, Isomer 2 MS: 540.2 [M−H]−.

Sources & evidence

ORD record
ord-b6d9dbc47d3a45159d373ec3e1f60522
Source dataset
uspto-grants-2010_10
Patent number
US07816557B2

Reaction notes

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