4-(Trifluoromethyl)phenylboronic acid → HCID 59518095, compound

HRID 1160945Notes

Reaction equation

HRID 1160945 reaction equation
C[O:2][C:3](=[O:32])[CH2:4][CH2:5][NH:6][C:7](=[O:31])[C:8]1[CH:13]=[CH:12][C:11]([CH:14]([S:21][C:22]2[CH:27]=[C:26]([CH3:28])[C:25](Br)=[C:24]([CH3:30])[CH:23]=2)[CH2:15][CH2:16][C:17]([F:20])([F:19])[F:18])=[CH:10][CH:9]=1.[F:33][C:34]([F:45])([F:44])[C:35]1[CH:40]=[CH:39][C:38](B(O)O)=[CH:37][CH:36]=1>>[CH3:28][C:26]1[CH:27]=[C:22]([S:21][CH:14]([C:11]2[CH:12]=[CH:13][C:8]([C:7]([NH:6][CH2:5][CH2:4][C:3]([OH:2])=[O:32])=[O:31])=[CH:9][CH:10]=2)[CH2:15][CH2:16][C:17]([F:18])([F:19])[F:20])[CH:23]=[C:24]([CH3:30])[C:25]=1[C:38]1[CH:39]=[CH:40][C:35]([C:34]([F:45])([F:44])[F:33])=[CH:36][CH:37]=1

Participants

3

Reactant 2

HCID 27343894-(Trifluoromethyl)phenylboronic acidHCID 67153631HCID 67153631, compound

Product 1

HCID 59518095HCID 59518095, compound

Procedure

The title compound is prepared in a manner substantially similar to Example 358 starting from 3-{4-[1-(4-bromo-3,5-dimethyl-phenylsulfanyl)-4,4,4-trifluoro-butyl]-benzoylamino}-propionic acid methyl ester and 4-trifluoromethyl phenyl boronic acid. MS: 582.3 [M−H]−.

Sources & evidence

ORD record
ord-2c6513856e6447aea9cb2c25c1eaa024
Source dataset
uspto-grants-2010_10
Patent number
US07816557B2

Reaction notes

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