(2,4-Dichlorophenyl)boronic acid → HCID 59518144, compound

HRID 1160948Notes

Reaction equation

HRID 1160948 reaction equation
C[O:2][C:3](=[O:29])[CH2:4][CH2:5][NH:6][C:7](=[O:28])[C:8]1[CH:13]=[CH:12][C:11]([CH:14]([O:19][C:20]2[CH:25]=[CH:24][C:23](Br)=[C:22]([Cl:27])[CH:21]=2)[CH2:15][CH:16]([CH3:18])[CH3:17])=[CH:10][CH:9]=1.[Cl:30][C:31]1[CH:36]=[C:35]([Cl:37])[CH:34]=[CH:33][C:32]=1B(O)O>>[CH3:18][CH:16]([CH3:17])[CH2:15][CH:14]([C:11]1[CH:12]=[CH:13][C:8]([C:7]([NH:6][CH2:5][CH2:4][C:3]([OH:2])=[O:29])=[O:28])=[CH:9][CH:10]=1)[O:19][C:20]1[CH:25]=[CH:24][C:23]([C:34]2[CH:33]=[CH:32][C:31]([Cl:30])=[CH:36][C:35]=2[Cl:37])=[C:22]([Cl:27])[CH:21]=1

Participants

3

Reactant 2

HCID 2734659(2,4-Dichlorophenyl)boronic acidHCID 67153439HCID 67153439, compound

Product 1

HCID 59518144HCID 59518144, compound

Procedure

The title compounds are prepared in a manner substantially similar to Example 24 starting from 3-{4-[1-(4-bromo-3-chloro-phenoxy)-3-methyl-butyl]-benzoylamino}-propionic acid methyl ester and 2,4-dichlorophenyl boronic acid. The isomers are resolved by methods described herein or known to one skilled in the art. Isomer 1 MS: 533.2 [M−H]−; Isomer 2 MS: 533.2 [M−H]−.

Sources & evidence

ORD record
ord-c8b99ebee6b24880bdb594e15159fb0d
Source dataset
uspto-grants-2010_10
Patent number
US07816557B2

Reaction notes

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