4-Isopropylphenylboronic acid → HCID 59518077, compound

HRID 1160949Notes

Reaction equation

HRID 1160949 reaction equation
C[O:2][C:3](=[O:33])[CH2:4][CH2:5][NH:6][C:7](=[O:32])[C:8]1[CH:13]=[CH:12][C:11]([CH:14]([O:22][C:23]2[CH:28]=[C:27]([CH3:29])[C:26](Br)=[C:25]([CH3:31])[CH:24]=2)[CH2:15][CH2:16][CH2:17][C:18]([F:21])([F:20])[F:19])=[CH:10][CH:9]=1.[CH:34]([C:37]1[CH:42]=[CH:41][C:40](B(O)O)=[CH:39][CH:38]=1)([CH3:36])[CH3:35]>>[F:20][C:18]([F:19])([F:21])[CH2:17][CH2:16][CH2:15][CH:14]([C:11]1[CH:12]=[CH:13][C:8]([C:7]([NH:6][CH2:5][CH2:4][C:3]([OH:2])=[O:33])=[O:32])=[CH:9][CH:10]=1)[O:22][C:23]1[CH:24]=[C:25]([CH3:31])[C:26]([C:40]2[CH:41]=[CH:42][C:37]([CH:34]([CH3:36])[CH3:35])=[CH:38][CH:39]=2)=[C:27]([CH3:29])[CH:28]=1

Participants

3

Reactant 2

HCID 27734804-Isopropylphenylboronic acidHCID 67153388HCID 67153388, compound

Product 1

HCID 59518077HCID 59518077, compound

Procedure

The title compounds are prepared in a manner substantially similar to Example 128 starting from 3-{4-[1-(4-bromo-3,5-dimethyl-phenoxy)-5,5,5-trifluoro-pentyl]-benzoylamino}-propionic acid methyl ester and 4-isopropyl phenyl boronic acid. Isomer 1 MS: 554.2 [M−H]−; Isomer 2 MS: 554.2 [M−H]−.

Sources & evidence

ORD record
ord-d6c43173872b47e28028290573685fa3
Source dataset
uspto-grants-2010_10
Patent number
US07816557B2

Reaction notes

Loading…