Ethylboronic acid → HCID 59518141, compound

HRID 1160968Notes

Reaction equation

C[O:2][C:3](=[O:33])[CH2:4][CH2:5][NH:6][C:7](=[O:32])[C:8]1[CH:13]=[CH:12][C:11]([CH:14]([O:22][C:23]2[CH:28]=[C:27]([CH3:29])[C:26](Br)=[C:25]([CH3:31])[CH:24]=2)[CH2:15][CH2:16][CH2:17][C:18]([F:21])([F:20])[F:19])=[CH:10][CH:9]=1.[CH2:34](B(O)O)[CH3:35]>>[CH2:34]([C:26]1[C:27]([CH3:29])=[CH:28][C:23]([O:22][CH:14]([C:11]2[CH:12]=[CH:13][C:8]([C:7]([NH:6][CH2:5][CH2:4][C:3]([OH:2])=[O:33])=[O:32])=[CH:9][CH:10]=2)[CH2:15][CH2:16][CH2:17][C:18]([F:21])([F:20])[F:19])=[CH:24][C:25]=1[CH3:31])[CH3:35]

Participants

Reactant 2

HCID 521157Ethylboronic acid

HCID 67153388HCID 67153388, compound

Product 1

HCID 59518141HCID 59518141, compound

Procedure

The title compound is prepared in a manner substantially similar to Example 128 starting from 3-{4-[1-(4-bromo-3,5-dimethyl-phenoxy)-5,5,5-trifluoro-pentyl]-benzoylamino}-propionic acid methyl ester and ethyl boronic acid. MS: 464.2 [M−H]−.

Sources & evidence

ORD record: ord-b410c490e754442088405f1d2dcda1cb
Source dataset: uspto-grants-2010_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07816557B2

Reaction notes

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