4-(Trifluoromethyl)phenylboronic acid → HCID 59518045, compound

HRID 1160969Notes

Reaction equation

HRID 1160969 reaction equation
C[O:2][C:3](=[O:33])[CH2:4][CH2:5][NH:6][C:7](=[O:32])[C:8]1[CH:13]=[CH:12][C:11]([CH:14]([O:22][C:23]2[CH:28]=[C:27]([CH3:29])[C:26](Br)=[C:25]([CH3:31])[CH:24]=2)[CH2:15][CH2:16][CH2:17][C:18]([F:21])([F:20])[F:19])=[CH:10][CH:9]=1.[F:34][C:35]([F:46])([F:45])[C:36]1[CH:41]=[CH:40][C:39](B(O)O)=[CH:38][CH:37]=1>>[CH3:31][C:25]1[CH:24]=[C:23]([O:22][CH:14]([C:11]2[CH:10]=[CH:9][C:8]([C:7]([NH:6][CH2:5][CH2:4][C:3]([OH:2])=[O:33])=[O:32])=[CH:13][CH:12]=2)[CH2:15][CH2:16][CH2:17][C:18]([F:20])([F:21])[F:19])[CH:28]=[C:27]([CH3:29])[C:26]=1[C:39]1[CH:40]=[CH:41][C:36]([C:35]([F:46])([F:45])[F:34])=[CH:37][CH:38]=1

Participants

3

Reactant 2

HCID 27343894-(Trifluoromethyl)phenylboronic acidHCID 67153388HCID 67153388, compound

Product 1

HCID 59518045HCID 59518045, compound

Procedure

The title compound is prepared in a manner substantially similar to Example 128 starting from 3-{4-[1-(4-bromo-3,5-dimethyl-phenoxy)-5,5,5-trifluoro-pentyl]-benzoylamino}-propionic acid methyl ester and 4-trifluoromethyl phenyl boronic acid. MS: 580.3 [M−H]−.

Sources & evidence

ORD record
ord-1c2331f5198842949df25ae29fea7e4f
Source dataset
uspto-grants-2010_10
Patent number
US07816557B2

Reaction notes

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