4-(Trifluoromethyl)phenylboronic acid → HCID 59518121, compound

HRID 1160972Notes

Reaction equation

HRID 1160972 reaction equation
C[O:2][C:3](=[O:31])[CH2:4][CH2:5][NH:6][C:7](=[O:30])[C:8]1[CH:13]=[CH:12][C:11]([CH:14]([O:22][C:23]2[CH:28]=[CH:27][C:26](Br)=[CH:25][CH:24]=2)[CH2:15][CH2:16][CH2:17][C:18]([F:21])([F:20])[F:19])=[CH:10][CH:9]=1.[F:32][C:33]([F:44])([F:43])[C:34]1[CH:39]=[CH:38][C:37](B(O)O)=[CH:36][CH:35]=1>>[F:19][C:18]([F:20])([F:21])[CH2:17][CH2:16][CH2:15][CH:14]([C:11]1[CH:12]=[CH:13][C:8]([C:7]([NH:6][CH2:5][CH2:4][C:3]([OH:2])=[O:31])=[O:30])=[CH:9][CH:10]=1)[O:22][C:23]1[CH:28]=[CH:27][C:26]([C:37]2[CH:38]=[CH:39][C:34]([C:33]([F:44])([F:43])[F:32])=[CH:35][CH:36]=2)=[CH:25][CH:24]=1

Participants

3

Reactant 2

HCID 27343894-(Trifluoromethyl)phenylboronic acidHCID 67153380HCID 67153380, compound

Product 1

HCID 59518121HCID 59518121, compound

Procedure

The title compound is prepared in a manner substantially similar to Example 128 starting from 3-{4-[1-(4-bromo-phenoxy)-5,5,5-trifluoro-pentyl]-benzoylamino}-propionic acid methyl ester and 4-trifluoromethyl phenyl boronic acid. Isomer 1 MS: 552.2 [M−H]−; Isomer 2 MS: 552.2 [M−H]−.

Sources & evidence

ORD record
ord-9069a537e7ad4fe9992d5b8ffa5c1a57
Source dataset
uspto-grants-2010_10
Patent number
US07816557B2

Reaction notes

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