4-(Trifluoromethyl)phenylboronic acid → HCID 59518050, compound

HRID 1160975Notes

Reaction equation

HRID 1160975 reaction equation
C[O:2][C:3](=[O:29])[CH2:4][CH2:5][NH:6][C:7](=[O:28])[C:8]1[CH:13]=[CH:12][C:11]([CH:14]([O:20][C:21]2[CH:22]=[N:23][C:24](Cl)=[CH:25][CH:26]=2)[CH2:15][CH2:16][CH2:17][CH2:18][CH3:19])=[CH:10][CH:9]=1.[F:30][C:31]([F:42])([F:41])[C:32]1[CH:37]=[CH:36][C:35](B(O)O)=[CH:34][CH:33]=1>>[F:30][C:31]([F:42])([F:41])[C:32]1[CH:37]=[CH:36][C:35]([C:24]2[N:23]=[CH:22][C:21]([O:20][CH:14]([C:11]3[CH:12]=[CH:13][C:8]([C:7]([NH:6][CH2:5][CH2:4][C:3]([OH:2])=[O:29])=[O:28])=[CH:9][CH:10]=3)[CH2:15][CH2:16][CH2:17][CH2:18][CH3:19])=[CH:26][CH:25]=2)=[CH:34][CH:33]=1

Participants

3

Reactant 2

HCID 27343894-(Trifluoromethyl)phenylboronic acidHCID 86615992HCID 86615992, compound

Product 1

HCID 59518050HCID 59518050, compound

Procedure

The title compounds are prepared in a manner substantially similar to Example 62 starting from 3-{4-[1-(6-chloro-pyridin-3-yloxy)-hexyl]-benzoylamino}-propionic acid methyl ester and 4-trifluoromethyl phenyl boronic acid. Isomer 1 MS: 513.3 [M−H]−; Isomer 2 MS: 513.3 [M−H]−.

Sources & evidence

ORD record
ord-72be80025c5b4bf0995e30c242b1b545
Source dataset
uspto-grants-2010_10
Patent number
US07816557B2

Reaction notes

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