4-(Trifluoromethyl)phenylboronic acid → HCID 59518160, compound

HRID 1160976Notes

Reaction equation

HRID 1160976 reaction equation
C[O:2][C:3](=[O:28])[CH2:4][CH2:5][NH:6][C:7](=[O:27])[C:8]1[CH:13]=[CH:12][C:11]([CH:14]([O:19][C:20]2[CH:21]=[N:22][C:23](Cl)=[CH:24][CH:25]=2)[CH2:15][CH2:16][CH2:17][CH3:18])=[CH:10][CH:9]=1.[F:29][C:30]([F:41])([F:40])[C:31]1[CH:36]=[CH:35][C:34](B(O)O)=[CH:33][CH:32]=1>>[F:29][C:30]([F:41])([F:40])[C:31]1[CH:36]=[CH:35][C:34]([C:23]2[N:22]=[CH:21][C:20]([O:19][CH:14]([C:11]3[CH:12]=[CH:13][C:8]([C:7]([NH:6][CH2:5][CH2:4][C:3]([OH:2])=[O:28])=[O:27])=[CH:9][CH:10]=3)[CH2:15][CH2:16][CH2:17][CH3:18])=[CH:25][CH:24]=2)=[CH:33][CH:32]=1

Participants

3

Reactant 2

HCID 27343894-(Trifluoromethyl)phenylboronic acidHCID 86615993HCID 86615993, compound

Product 1

HCID 59518160HCID 59518160, compound

Procedure

The title compounds are prepared in a manner substantially similar to Example 62 starting from 3-{4-[1-(6-chloro-pyridin-3-yloxy)-pentyl]-benzoylamino}-propionic acid methyl ester and 4-trifluoromethyl phenyl boronic acid. Isomer 1 MS: 499.2 [M−H]−; Isomer 2 MS: 499.2 [M−H]−.

Sources & evidence

ORD record
ord-468e3adcac014a2999deb93f72a959e2
Source dataset
uspto-grants-2010_10
Patent number
US07816557B2

Reaction notes

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