Hydrochloric Acid → HCID 13463080, compound

Participants

Reaction Steps

To N1-(4-acetyl-3-hydroxy-2-propylphenyl)acetamide (1.0 g, 4.3 mmol) in absolute ethanol (15 mL) is added 6N HCl (15 mL). The reaction mixture is refluxed for 3 h. The reaction mixture is cooled to RT and quenched into saturated aqueous NaHCO3. The mixture is extracted with EtOAc (3×). The organic layers are combined, washed with brine, dried over Na2SO4 and concentrated. Obtained is the title compound (827 mg, 99%). LC-MS (m/e): 194 (M+1).

Provenance & Evidence