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HRID 1161145作成日：2026年10月25日
Lithium Carbonate → 1-{2-Hydroxy-4-[3-(3-iodo-benzyl)-[1,2,4]oxadiazol-5-ylmethoxy]-3-methyl-phenyl}-ethanone
https://huagongshe.com/reaction/1161145
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Lithium Carbonate | HCID 11125 | — |
| 反応物 | 3-(3-Amino-1,2,4-oxadiazol-5-yl)-1-azabicyclo(2.2.1)heptane | HCID 163938 | — |
| 反応物 | 1-(2,4-Dihydroxy-3-methylphenyl)ethan-1-one | HCID 592139 | — |
| 反応物 | 5-Chloromethyl-3-(3-iodo-benzyl)-[1,2,4]oxadiazole | HCID 57438412 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 1-{2-Hydroxy-4-[3-(3-iodo-benzyl)-[1,2,4]oxadiazol-5-ylmethoxy]-3-methyl-phenyl}-ethanone | HCID 66699621 | 53.8% |
反応手順
Add lithium carbonate (49 mg, 0.66 mmol) and 5-chloromethyl-3-(3-iodo-benzyl)-[1,2,4]oxadiazole (200 mg, 0.60 mmol) to a solution of 1-(2,4-dihydroxy-3-methyl-phenyl)-ethanone (110 mg, 0.66 mmol) in anhydrous dimethylformamide (20 mL) 4]oxadiazole (200 mg, 0.60 mmol). Heat the reaction mixture at 60° C. overnight. Cool the reaction mixture to RT, pour into H2O, and extract with diethyl ether (3×). Combine the organic layers, wash with brine, dry over sodium sulfate, and concentrate to provide the title compound (150 mg). LC-MS (m/e): 463 (M−1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US07816523B2 |
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| 出典データセット | uspto-grants-2010_10 |
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| ORD ID | ord-0894953b1a8b4ccaaaacef27a1a9f109 |
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| 出典メモ | uspto-grants-2010_10 |
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