5-Chloromethyl-3-(3-iodo-benzyl)-[1,2,4]oxadiazole → 5-Chloromethyl-3-(4-iodo-benzyl)-[1,2,4]oxadiazole

HRID 1161149Notes

Reaction equation

HRID 1161149 reaction equation
[Cl:1][CH2:2][C:3]1[O:7][N:6]=[C:5]([CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11](I)[CH:10]=2)[N:4]=1.ONC(=N)CC1C=CC([I:26])=CC=1>>[Cl:1][CH2:2][C:3]1[O:7][N:6]=[C:5]([CH2:8][C:9]2[CH:14]=[CH:13][C:12]([I:26])=[CH:11][CH:10]=2)[N:4]=1

Participants

3

Reactant 2

HCID 574384125-Chloromethyl-3-(3-iodo-benzyl)-[1,2,4]oxadiazoleHCID 178510823N-Hydroxy-2-(4-iodophenyl)acetimidamide

Product 1

HCID 574384135-Chloromethyl-3-(4-iodo-benzyl)-[1,2,4]oxadiazole

Procedure

The title compound is prepared essentially as described for 5-chloromethyl-3-(3-iodo-benzyl)-[1,2,4]oxadiazole, employing N-hydroxy-2-(4-iodo-phenyl)-acetamidine. LC-MS (m/e): 335 (M+1).

Sources & evidence

ORD record
ord-8ab9a5581a6541d392fee421d11dbed2
Source dataset
uspto-grants-2010_10
Patent number
US07816523B2

Reaction notes

Loading…