HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1161177Generated: October 29, 2026
Dimethylformamide dimethyl acetal → (E)-Methyl 2-(2-(dimethylamino)vinyl)-3-nitrobenzoate
https://huagongshe.com/reaction/1161177
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| Reactant | Methyl 2-methyl-3-nitrobenzoate | HCID 601165 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | (E)-Methyl 2-(2-(dimethylamino)vinyl)-3-nitrobenzoate | HCID 12148522 | — |
Reaction Steps
A mixture of methyl 2-methyl-3-nitrobenzoate (5.0 g, 25.6 mmol) and N,N-dimethylformamide dimethyl acetal (9.18 g, 77 mmol) in DMF (30 mL) was stirred at 115° C. for 17 h. The volatiles were removed under reduced pressure to give (E)-methyl 2-(2-(dimethylamino)-vinyl)-3-nitrobenzoate as brown oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07816371B2 |
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| Source dataset | uspto-grants-2010_10 |
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| ORD ID | ord-e8492669042945fc97291adf933c5c90 |
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| Source note | uspto-grants-2010_10 |
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