HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1161205Generated: October 29, 2026
Methanol → 2-(5-Nitro-1-oxoisoquinolin-2(1H)-yl)acetamide
https://huagongshe.com/reaction/1161205
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Glycinamide hydrochloride | HCID 2723639 | — |
| Reactant | 5-nitro-1H-isochromen-1-one | HCID 10012760 | — |
| Reactant | Triethylaluminum | HCID 16682930 | — |
| Product | 2-(5-Nitro-1-oxoisoquinolin-2(1H)-yl)acetamide | HCID 59515738 | — |
Reaction Steps
A round bottom flask was charged with 5-nitro-isochromen-1-one (2.5 g, 0.013 mol), methanol (50 mL, 1 mol), glycinamide hydrochloride (3.0 g, 0.027 mol) and triethylaluminum (4.4 mL, 0.033 mol) and heated at 85° C. for 3 hours. The solvent was removed under reduced pressure to get the product as a yellow solid. MS m/z=248.2 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07816371B2 |
|---|
| Source dataset | uspto-grants-2010_10 |
|---|
| ORD ID | ord-eee6a1a50cba44d7bdd648036cc28789 |
|---|
| Source note | uspto-grants-2010_10 |
|---|
