Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 5-nitro-1H-isochromen-1-one | HCID 10012760 | — |
| Reactant | L-Serinamide hydrochloride | HCID 16212403 | — |
| Product | HCID 59515781 | HCID 59515781 | — |
Reaction Steps
A round bottom flask was charged with 5-nitro-isochromen-1-one (2 g, 0.01 mol), methanol (40 mL, 1 mol), (S)-2-amino-3-hydroxypropanamide hydrochloride (2.2 g, 0.016 mol) and triethylamine (2.55 mL, 0.0183 mol) and stirred at 52° C. overnight. The product precipitated out and was filtered and dried to yield the pure product as a yellow solid. MS m/z=278.3 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07816371B2 |
|---|
| Source dataset | uspto-grants-2010_10 |
|---|
| ORD ID | ord-777039749a5f45759a58efd3b375a755 |
|---|
| Source note | uspto-grants-2010_10 |
|---|
