反应详情

A round bottom flask was charged with (R)-methyl 3-hydroxy-2-(5-nitro-1-oxoisoquinolin-2(1H)-yl)propanoate (4 g, 0.01 mol) and methylene chloride (40 mL, 0.5 mol) and 1H-imidazole (1.6 g, 0.023 mol) and tert-butyldimethylsilyl chloride (2.3 g, 0.015 mol) were added at 0° C. and the reaction allowed to warm to room temperature and stirred for 16 h. The reaction mixture was quenched with water and extracted with methylene chloride. Solvent was removed under reduced pressure to yield pure product. MS m/z=407.5 (M+H).

1. additionwere added at 0° C.
2. customThe reaction mixture was quenched with water
3. extractionextracted with methylene chloride
4. customSolvent was removed under reduced pressure
5. customto yield pure product