HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1161217Generated: October 29, 2026
Methanol → (R)-2-(5-Nitro-1-oxoisoquinolin-2(1H)-yl)propanamide
https://huagongshe.com/reaction/1161217
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | (2R)-2-Aminopropanamide hydrochloride | HCID 2775814 | — |
| Reactant | 5-nitro-1H-isochromen-1-one | HCID 10012760 | — |
| Product | (R)-2-(5-Nitro-1-oxoisoquinolin-2(1H)-yl)propanamide | HCID 59515648 | — |
Reaction Steps
To a solution of 5-nitro-isochromen-1-one (2 g, 0.01 mol) in methanol (40 mL, 1 mol) was added (R)-2-aminopropanamide hydrochloride (2.0 g, 0.016 mol) and triethylamine (2.6 mL, 0.019 mol) and stirred at 52° C. for 3 hr. The product (yellow solid) precipitated out and was filtered and carried on to the next reaction. MS m/z=262.1 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07816371B2 |
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| Source dataset | uspto-grants-2010_10 |
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| ORD ID | ord-889dd0df1b734235a800b64cbfcf6a07 |
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| Source note | uspto-grants-2010_10 |
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