HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1161224Generated: October 30, 2026
Methylamine → (2R)-3-(tert-Butyldimethylsilyloxy)-2-(5-(2-(3,4-dichlorophenyl)propanamido)-1-oxoisoquinolin-2(1H)-yl)-N-methylpropanamide
https://huagongshe.com/reaction/1161224
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | (2R)-Methyl 3-(tert-butyldimethylsilyloxy)-2-(5-(2-(3,4-dichlorophenyl)propanamido)-1-oxoisoquinolin-2(1H)-yl)propanoate | HCID 67087983 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (2R)-3-(tert-Butyldimethylsilyloxy)-2-(5-(2-(3,4-dichlorophenyl)propanamido)-1-oxoisoquinolin-2(1H)-yl)-N-methylpropanamide | HCID 58973958 | — |
Reaction Steps
A mixture of (2R)-methyl 3-(tert-butyldimethylsilyloxy)-2-(5-(2-(3,4-dichlorophenyl)propanamido)-1-oxoisoquinolin-2(1H)-yl)propanoate (200 mg, 0.0003 mol), 5 mL of methylamine and tetrahydrofuran (2M) was heated in a sealed tube to 70° C. overnight. The reaction was only partially complete. The solvent was removed and the residue purified by flash chromatography to obtain the product as a light yellow oil. MS m/z=577.4 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07816371B2 |
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| Source dataset | uspto-grants-2010_10 |
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| ORD ID | ord-40ec951a6566479899aa807cfb338983 |
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| Source note | uspto-grants-2010_10 |
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