HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 59515872, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 5-nitro-1H-isochromen-1-one | HCID 10012760 | — |
| Reactant | (2R)-2-amino-3-methylbutanamide hydrochloride | HCID 53486046 | — |
| Product | HCID 59515872 | HCID 59515872 | — |
Reaction Steps
5-Nitro-isochromen-1-one (2 g, 0.01 mol) and H-D-Val-NH2HCl (1.9 g, 0.012 mol) were refluxed in methanol (40 mL, 1 mol) with triethylamine (5 g, 0.05 mol) for 2 hours. The volatiles were removed via rotovapor, and the residue was purified via flash column chromatography (40 g of silica gel, 0-30% EtOAc/Hexane) to give a yellow solid. MS m/z 290.2 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07816371B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-01c5bfa0869c4b6ea2628ec7e45b848f |
| Source note | uspto-grants-2010_10 |