HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → (R)-2-(5-Amino-1-oxoisoquinolin-2(1H)-yl)-N-cyclopropylpropanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | (R)-N-Cyclopropyl-2-(5-nitro-1-oxoisoquinolin-2(1H)-yl)propanamide | HCID 59515780 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Product | (R)-2-(5-Amino-1-oxoisoquinolin-2(1H)-yl)-N-cyclopropylpropanamide | HCID 59515716 | — |
Reaction Steps
(R)-N-Cyclopropyl-2-(5-nitro-1-oxoisoquinolin-2(1H)-yl)propanamide (0.6 g, 0.002 mol) was stirred with palladium 10% wt. on calcium carbonate (0.1 g, 0.00005 mol) in methanol (30 mL, 0.7 mol) under hydrogen (balloon) over 1 h at room temperature. The catalyst was filtered, the filtrate was concentrated to dryness gave a brown solid. MS m/z 271.7 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07816371B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-f0f57e1c90de42ebb5825b0d0fe347b4 |
| Source note | uspto-grants-2010_10 |