HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1161250Generated: October 29, 2026
Methanol → Methyl 2-(4-chlorophenyl)-2-(5-nitro-1-oxoisoquinolin-2(1H)-yl)acetate
https://huagongshe.com/reaction/1161250
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 5-nitro-1H-isochromen-1-one | HCID 10012760 | — |
| Reactant | Methyl 2-amino-2-(4-chlorophenyl)acetate hydrochloride | HCID 12803949 | — |
| Product | Methyl 2-(4-chlorophenyl)-2-(5-nitro-1-oxoisoquinolin-2(1H)-yl)acetate | HCID 58973969 | — |
Reaction Steps
A round bottom flask was charged with 5-nitro-isochromen-1-one (2.5 g, 0.013 mol), methanol (40 mL, 1 mol), triethylamine (4 mL, 0.03 mol) and methyl 2-amino-2-(4-chlorophenyl)acetate hydrochloride (4.0 g, 0.017 mol) and the reaction heated at 50° C. for 4 hours. The solvent was removed and the residue purified by flash chromatography (40 g silica gel, 0-10% MOH/DCM) to yield the product as a yellow solid. MS m/z=373.3 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07816371B2 |
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| Source dataset | uspto-grants-2010_10 |
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| ORD ID | ord-702adf24d1954e118f899294b8cfd5fd |
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| Source note | uspto-grants-2010_10 |
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