反应详情

温度

70 °C

A pressure tube was charged with methyl 2-(5-amino-1-oxoisoquinolin-2(1H)-yl)-2-(4-chlorophenyl)acetate (1.35 g, 0.00394 mol) and ammonia in methanol (7 mL, 2M solution) was added and the reaction heated at 70° C. for 16 hours. The reaction mixture was cooled to room temperature and checked for completion. The reaction was only 20% complete. Further heating of the reaction for another 6 hours did not seem to help in the progress of the reaction. The solvent was removed and the residue was purified by flash chromatography to obtain the product as a light yellow solid. MS m/z=328.2 (M+H).

1. additionwas added
2. temperatureThe reaction mixture was cooled to room temperature
3. temperatureFurther heating of the reaction for another 6 hours
4. customto help in the progress of the reaction
5. customThe solvent was removed
6. customthe residue was purified by flash chromatography