HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1161254Generated: October 30, 2026
Methanol → (R)-2-(6-Chloro-5-nitro-1-oxoisoquinolin-2(1H)-yl)propanamide
https://huagongshe.com/reaction/1161254
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | (2R)-2-Aminopropanamide hydrochloride | HCID 2775814 | — |
| Reactant | 6-Chloro-5-nitro-1H-isochromen-1-one | HCID 59515725 | — |
| Product | (R)-2-(6-Chloro-5-nitro-1-oxoisoquinolin-2(1H)-yl)propanamide | HCID 59515858 | — |
Reaction Steps
A round bottom flask was charged with 6-chloro-5-nitro-1H-isochromen-1-one (950 mg, 0.0042 mol), methanol (30 mL, 0.7 mol), triethylamine (0.64 mL, 0.0046 mol) and (R)-2-aminopropanamide hydrochloride (0.58 g, 0.0046 mol) and the reaction heated to 55° C. overnight. The reaction went to 90% completion. The solvent was removed and the residue purified by flash chromatography (40 g silica gel, 0-10% MeOH/DCM) to obtain the pure product as a light yellow solid. MS m/z=296.4 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07816371B2 |
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| Source dataset | uspto-grants-2010_10 |
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| ORD ID | ord-36837f9d697c4b529416a29e9df5e147 |
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| Source note | uspto-grants-2010_10 |
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