HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1161255Generated: October 26, 2026
Ethanol → (R)-2-(5-Amino-6-chloro-1-oxoisoquinolin-2(1H)-yl)propanamide
https://huagongshe.com/reaction/1161255
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | (R)-2-(6-Chloro-5-nitro-1-oxoisoquinolin-2(1H)-yl)propanamide | HCID 59515858 | — |
| Catalyst | Iron | HCID 23925 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | (R)-2-(5-Amino-6-chloro-1-oxoisoquinolin-2(1H)-yl)propanamide | HCID 59515791 | — |
Reaction Steps
A round bottom flask was charged with (R)-2-(6-chloro-5-nitro-1-oxoisoquinolin-2(1H)-yl)propanamide (120 mg, 0.00040 mol), ethanol (4 mL, 0.07 mol) and ammonium chloride (200 mg, 0.004 mol) in water (4 mL, 0.2 mol) was added and the reaction heated at 85° C. and iron (90 mg, 0.002 mol) was added in two portions 5 minutes apart. The reaction was stirred at that temperature for 30 minutes and ethylacetate was added and decanted. The solvent was removed to get the product as yellow solid. MS m/z=266.2 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07816371B2 |
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| Source dataset | uspto-grants-2010_10 |
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| ORD ID | ord-0730d73c74504705827c3bdbc18bcbe0 |
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| Source note | uspto-grants-2010_10 |
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