HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1161268Generated: October 29, 2026
Methanol → (S)-2-(6-Chloro-5-nitro-1-oxoisoquinolin-2(1H)-yl)propanamide
https://huagongshe.com/reaction/1161268
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | (S)-2-aminopropanamide hydrochloride | HCID 2775816 | — |
| Reactant | 6-Chloro-5-nitro-1H-isochromen-1-one | HCID 59515725 | — |
| Product | (S)-2-(6-Chloro-5-nitro-1-oxoisoquinolin-2(1H)-yl)propanamide | HCID 59515834 | — |
Reaction Steps
A mixture of 6-chloro-5-nitro-1H-isochromen-1-one (230 mg, 0.00102 mol), (S)-2-aminopropanamide hydrochloride (127 mg, 0.00102 mol), triethylamine (142 μL, 0.00102 mol) and methanol (20 mL, 0.5 mol) was stirred at 60° C. for 3 hours. The solvent was removed and the residue purified by flash chromatography to obtain the product as a yellow solid. MS m/z=262.3 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07816371B2 |
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| Source dataset | uspto-grants-2010_10 |
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| ORD ID | ord-eed38aa5b79e446ab8d22d7845f3016c |
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| Source note | uspto-grants-2010_10 |
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