Ethanol → (S)-2-(5-Amino-6-chloro-1-oxoisoquinolin-2(1H)-yl)propanamide

Participants

Reaction Conditions

Reaction Steps

A mixture of (S)-2-(6-chloro-5-nitro-1-oxoisoquinolin-2(1H)-yl)propanamide (201 mg, 0.000679 mol), ethanol (10 mL, 0.2 mol), ammonium chloride (363.03 mg, 0.0067868 mol) and water (10 mL, 0.6 mol) was heated at 85° C. and iron (152 mg, 0.00271 mol) was added in three portions 2 minutes apart. The reaction was stirred at that temperature for 1 hour and poured into dichloromethane (150 mL) and the layers were separated. The organic layer was washed with brine, dried over sodium sulfate and the solvent removed under reduced pressure to obtain the pure product as a light yellow solid. MS m/z=232.5 (M+H).

Provenance & Evidence