Ethanol → (R)-2-(5-amino-6-methyl-1-oxoisoquinolin-2(1H)-yl)propyl acetate

Participants

Reaction Conditions

Reaction Steps

A round bottom flask was charged with (R)-2-(6-methyl-5-nitro-1-oxoisoquinolin-2(1H)-yl)propyl acetate (110.0 mg, 0.0003615 mol), ethanol (10 mL, 0.2 mol) and the reaction heated at 85° C. and ammonium chloride (193.4 mg, 0.003615 mol) in water (2 mL, 0.1 mol) was added followed by iron (80.7 mg, 0.00144 mol) in two portions and continued to heat for 30 minutes. The reaction went to completion and was poured into DCM (50 mL) and extracted. The removal of the solvent under reduced pressure gave the pure product as an oil. MS m/z=275.4 (M+H).

Provenance & Evidence