反应详情
EQUATION
反应方程式
REACTANTS
反应物
N,N-Dimethylformamide
C3H7NO
Diisopropylethylamine
C8H19N
3-Fluoro-4-(trifluoromethyl)phenylacetic acid
C9H6F4O2
Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)
C10H15F6N6OP
未命名化合物
PRODUCTS
生成物
CONDITIONS
反应条件
- 温度
- 45 °C
PROCEDURE
实验过程
A round bottom flask was charged with (R)-2-(5-amino-6-methyl-1-oxoisoquinolin-2(1H)-yl)propyl acetate (175 mg, 0.000638 mol), 2-(3-fluoro-4-(trifluoromethyl)phenyl)acetic acid (210 mg, 0.00096 mol), N,N,N′,N′-tetramethyl-O-(7-azabenzotriazol-1-yl)uronium hexafluorophosphate (610 mg, 0.0016 mol), N,N-diisopropylethylamine (0.28 mL, 0.0016 mol) and N,N-dimethylformamide (8 mL, 0.1 mol) and the reaction stirred at 45° C. for 24 hours. The reaction did not go to completion. The reaction was then quenched with water and extracted with ethyl acetate, washed with NaHCO3, brine and dried. The solvent was removed under reduced pressure and the residue purified by flash chromatography to obtain the product as a light yellow oil. MS m/z=479.3 (M+H)
WORKUP
后处理
- customThe reaction was then quenched with water
- extractionextracted with ethyl acetate
- washwashed with NaHCO3, brine
- customdried
- customThe solvent was removed under reduced pressure
- customthe residue purified by flash chromatography