Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2-Fluoro-3-(trifluoromethyl)phenylacetic acid | HCID 2737588 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 59515926 | HCID 59515926 | — |
| Product | HCID 59515734 | HCID 59515734 | — |
Reaction Steps
A reaction vial was charged with acetic acid 2-[6-(2-acetoxy-ethylamino)-5-amino-1-oxo-1H-isoquinolin-2-yl]-ethyl ester (100.00 mg, 0.00028788 mol), 2-(2-fluoro-3-(trifluoromethyl)phenyl)acetic acid (76.74 mg, 0.0003454 mol), N,N,N′,N′-tetramethyl-O-(7-azabenzotriazol-1-yl)uronium hexafluorophosphate (274 mg, 0.000720 mol), N,N-diisopropylethylamine (0.125 mL, 0.000720 mol) and methylene chloride (3 mL, 0.05 mol) and the reaction heated at 40° C. for 5 h. The solvent was removed and the residue purified by flash chromatography to obtain the product as an off white solid. MS m/z=552.3 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07816371B2 |
|---|
| Source dataset | uspto-grants-2010_10 |
|---|
| ORD ID | ord-a71485c61de147a38adb639418f8bfb3 |
|---|
| Source note | uspto-grants-2010_10 |
|---|
