Methanol → HCID 59515935, compound

Participants

Reaction Steps

Into a round bottom flask was combined 5-nitro-isochromen-1-one (5.00 g, 0.0235 mol), N-Acetylethylenediamine (7.21 g, 0.0706 mol) and methanol (150 mL, 3.7 mol). The mixture was heated at reflux for 1.5 hours. The mixture was cooled to room temperature and was stirred overnight. LC-MS showed that the starting material was completely consumed. Volatiles were removed and the resulting oil was purified in a methanol:methylene chloride (0-10%) gradient. Fractions containing the desired product, as determined by TLC and LC-MS, were combined and concentrated to produce a yellow solid.

Provenance & Evidence