Ethanol → HCID 59515672, compound

HRID 1161299Notes

Reaction equation

HRID 1161299 reaction equation
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][N:8]([CH2:15][CH2:16][NH:17][C:18](=[O:20])[CH3:19])[C:9]2=[O:14])([O-])=O.C(O)C>[Pd]>[NH2:1][C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][N:8]([CH2:15][CH2:16][NH:17][C:18](=[O:20])[CH3:19])[C:9]2=[O:14]

Participants

4

Reactant 2

HCID 702EthanolHCID 59515935HCID 59515935, compound

Product 1

HCID 59515672HCID 59515672, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Into a round bottom flask was combined N-(2-(5-nitro-1-oxoisoquinolin-2(1H)-yl)ethyl)acetamide (3.27 g, 0.0119 mol), palladium on C (1.6 g, 0.015 mol) and ethanol (250 mL, 4.2 mol). The reaction mixture was stirred under hydrogen at room temperature overnight. The mixture was filtered over celite, volatiles were removed under vacuum producing the title compound as a yellow solid. The compound was taken to the next step without further purification.

Workup

  1. customInto a round bottom flask was combined
  2. filtrationThe mixture was filtered over celite, volatiles
  3. customwere removed under vacuum

Sources & evidence

ORD record
ord-34c803fcfbf2405c9f74742fa6899f8f
Source dataset
uspto-grants-2010_10
Patent number
US07816371B2

Reaction notes

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